Studio of the Year
- BioWare
- Blizzard Entertainment
- Bungie Studios
- Rockstar San Diego
Best Shooter
- Battlefield: Bad Company 2
- BioShock 2
– Call of Duty: Black Ops
- Halo: Reach
Best Action-Adventure Game
- Assassin’s Creed: Brotherhood
- God of War III
- Red Dead Redemption
- Super Mario Galaxy 2
Best RPG
- Fable III
- Fallout: New Vegas
- Final Fantasy XIII
– Mass Effect 2
Best Team Sports Game
- FIFA Soccer 11
- Madden NFL 11
- NBA 2K11
- MLB ’10: The Show
Best Driving Game
- Blur
- ModNation Racers
– Need For Speed: Hot Pursuit
- Split/Second
Best Music Game
- Dance Central
- DJ Hero 2
- Def Jam Rapstar
– Rock Band 3
Best Soundtrack
- Def Jam Rapstar
– DJ Hero 2
- Guitar Hero: Warriors of Rock
- Rock Band 3
Best Original Score
- God of War III
- Halo: Reach
- Mass Effect 2
– Red Dead Redemption
Best Adapted Video Game
- LEGO: Harry Potter: Years 1-4
– Scott Pilgrim vs. The World: The Game
- Spider-Man: Shattered Dimensions
- Star Wars: The Force Unleashed II
- Transformers: War for Cybertron
Best Performance by a Human Male
- Daniel Craig as James Bond
- Gary Oldman as Sgt. Reznov
- John Cleese as Jasper
- Martin Sheen as Illusive Man
- Nathan Fillion as Sergeant Edward Buck
- Neil Patrick Harris as Peter Parker/Amazing Spider-Man
- Rob Wiethoff as John Marston
- Sam Worthington as Alex Mason
Best DLC
- BioShock 2: Minerva’s Den
- Borderlands: The Secret Armory of General Knoxx
- Mass Effect 2: Lair of the Shadow Broker
– Red Dead Redemption – Undead Nightmare
Best Independent Game
- Joe Danger
– Limbo
- Super Meat Boy
- The Misadventures of P.B. Winterbottom
Most Anticipated Game
- Batman: Arkham City
- BioShock: Infinite
- Gears of War 3
– Portal 2